4OLF: Crystal Structure of Prolyl-tRNA synthetase (ProRS, Proline--tRNA ligase)from Plasmodium falciparum in complex with Halofuginone and AMPPNP

PDB ID: 4OLFDownload
MMDB ID: 128546
PDB Deposition Date: 2014/1/23
Updated in MMDB: 2023/09
Experimental Method:
x-ray diffraction
Resolution: 2.9  Å
Source Organism:
Similar Structures:
Biological Unit for 4OLF: monomeric; determined by author
Molecular Components in 4OLF
Label Count Molecule
Protein (1 molecule)
1
Proline--trna Ligase
(Gene symbol: PF3D7_1213800)
Molecule annotation
Chemicals and Non-standard biopolymers (19 molecules)
1
1
PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER (Link to PubChem not yet available)PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER
2
1
7-bromo-6-chloro-3-{3-[(2R,3S)-3-hydroxypiperidin-2-yl]-2-oxopropyl}quinazolin-4(3H)-one (Link to PubChem not yet available)7-bromo-6-chloro-3-{3-[(2R,3S)-3-hydroxypiperidin-2-yl]-2-oxopropyl}quinazolin-4(3H)-one
3
15
SULFATE ION (Link to PubChem not yet available)SULFATE ION
4
1
SODIUM ION (Link to PubChem not yet available)SODIUM ION
5
1
1,2-ETHANEDIOL (Link to PubChem not yet available)1,2-ETHANEDIOL
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303