National Center for
4O6H: 2.8A crystal structure of Lymphocytic Choriomeningitis Virus Nucleoprotein C-terminal Domain
Structure of the LCMV nucleoprotein provides a template for understanding arenavirus replication and immunosuppression
Acta Crystallogr. D Biol. Crystallogr. (2014) 70 p.1764-1769
The X-ray crystal structure of the Lymphocytic choriomeningitis virus nucleoprotein C-terminal immunosuppressive domain (LCMV NPDelta340) was determined to 2.0 A resolution. The structure indicates that LCMV NPDelta340, like the other structurally characterized arenaviral nucleoproteins, adopts the fold of an exonuclease. This structure provides a crucial three-dimensional template for functional exploration of the replication and immunosuppression of this prototypic arenavirus.