National Center for
4NW5: Rsk2 N-terminal Kinase In Complex With 2-amino-7-substituted Benzoxazole Compound 8
Bioorg. Med. Chem. Lett. (2014) 24 p.1592-1596
2-Amino-7-substituted benzoxazole analogs were identified by HTS as inhibitors of RSK2. Molecular modeling and medicinal chemistry techniques were employed to explore the SAR for this series with a focus of improving in vitro and target modulation potency and physicochemical properties.