National Center for
4NTP: Crystal structure of macrocycles containing A 17-23 (LV(PHI)FAED) and A 30-36 (AII(SAR)L(ORN)V)
X-ray crystallographic structures of trimers and higher-order oligomeric assemblies of a peptide derived from Abeta(17-36)
J. Am. Chem. Soc. (2014) 136 p.5595-5598
A peptide derived from Abeta17-36 crystallizes to form trimers that further associate to form higher-order oligomers. The trimers consist of three highly twisted beta-hairpins in a triangular arrangement. Two trimers associate face-to-face in the crystal lattice to form a hexamer; four trimers in a tetrahedral arrangement about a central cavity form a dodecamer. These structures provide a working model for the structures of oligomers associated with neurodegeneration in Alzheimer's disease.