4NTP: Crystal structure of macrocycles containing A 17-23 (LV(PHI)FAED) and A 30-36 (AII(SAR)L(ORN)V)

A peptide derived from Abeta17-36 crystallizes to form trimers that further associate to form higher-order oligomers. The trimers consist of three highly twisted beta-hairpins in a triangular arrangement. Two trimers associate face-to-face in the crystal lattice to form a hexamer; four trimers in a tetrahedral arrangement about a central cavity form a dodecamer. These structures provide a working model for the structures of oligomers associated with neurodegeneration in Alzheimer's disease.
PDB ID: 4NTPDownload
MMDB ID: 118848
PDB Deposition Date: 2013/12/2
Updated in MMDB: 2018/07
Experimental Method:
x-ray diffraction
Resolution: 1.987  Å
Source Organism:
Similar Structures:
Biological Unit for 4NTP: hexadecameric; determined by author
Molecular Components in 4NTP
Label Count Molecule
Proteins (16 molecules)
Cyclic Hexadecapeptide (Orn)lv(phi)faed(orn)aii(sar)l(orn)v
Molecule annotation
Chemicals (7 molecules)
* Click molecule labels to explore molecular sequence information.

Citing MMDB