4NRB: Crystal Structure Of The Bromodomain Of Human Baz2b In Complex With Compound-1 N01197

Citation:
Abstract
Bromodomains are epigenetic reader domains that have recently become popular targets. In contrast to BET bromodomains, which have proven druggable, bromodomains from other regions of the phylogenetic tree have shallower pockets. We describe successful targeting of the challenging BAZ2B bromodomain using biophysical fragment screening and structure-based optimization of high ligand-efficiency fragments into a novel series of low-micromolar inhibitors. Our results provide attractive leads for development of BAZ2B chemical probes and indicate the whole family may be tractable.
PDB ID: 4NRBDownload
MMDB ID: 116310
PDB Deposition Date: 2013/11/26
Updated in MMDB: 2013/12
Experimental Method:
x-ray diffraction
Resolution: 2.08  Å
Source Organism:
Similar Structures:
Biological Unit for 4NRB: monomeric; determined by author and by software (PISA)
Molecular Components in 4NRB
Label Count Molecule
Protein (1 molecule)
1
Bromodomain Adjacent to Zinc Finger Domain Protein 2B(Gene symbol: BAZ2B)
Molecule annotation
Chemicals (2 molecules)
1
1
2
1
* Click molecule labels to explore molecular sequence information.

Citing MMDB
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