4NKJ: Structure Of Influenza B Virus Hemagglutinin At Membrane Fusion Ph

Membrane fusion is involved in many fundamental cellular processes and entry of enveloped viruses into host cells. Influenza type A virus HA has long served as a paradigm for mechanistic studies of protein-mediated membrane fusion via large-scale structural rearrangements induced by acidic pH. Here we report the newly determined crystal structure of influenza B virus HA2 in the postfusion state. Together with a large number of previously determined prefusion structures of influenza A and B virus HA and a postfusion structure of influenza A/H3N2 HA2, we identified conserved features that are shared between influenza A and B virus HA in the conformational transition and documented substantial differences that likely influence the detailed mechanisms of this process. Further studies are needed to dissect the effects of these and other structural differences in HA conformational changes and influenza pathogenicity and transmission, which may ultimately expedite the discovery of novel anti-influenza fusion inhibitors.
PDB ID: 4NKJDownload
MMDB ID: 118846
PDB Deposition Date: 2013/11/12
Updated in MMDB: 2014/04
Experimental Method:
x-ray diffraction
Resolution: 2.45  Å
Source Organism:
Similar Structures:
Biological Unit for 4NKJ: trimeric; determined by author and by software (PISA)
Molecular Components in 4NKJ
Label Count Molecule
Proteins (3 molecules)
Hemagglutinin HA2
Molecule annotation
* Click molecule labels to explore molecular sequence information.

Citing MMDB