4NKF: The effects of Lysine 200 and Phenylalanine 239 Farnesyl Pyrophosphate Synthase (FPPS) mutations on the catalytic activity, crystal structure and inhibition by nitrogen containing bisphosphonates

PDB ID: 4NKFDownload
MMDB ID: 124832
PDB Deposition Date: 2013/11/12
Updated in MMDB: 2014/11
Experimental Method:
x-ray diffraction
Resolution: 2  Å
Source Organism:
Similar Structures:
Biological Unit for 4NKF: dimeric; determined by author and by software (PISA)
Molecular Components in 4NKF
Label Count Molecule
Proteins (2 molecules)
2
Farnesyl Pyrophosphate Synthase
(Gene symbol: FDPS)
Molecule annotation
Chemicals and Non-standard biopolymers (12 molecules)
1
6
MAGNESIUM IONMAGNESIUM ION
2
2
PAMIDRONATEPAMIDRONATE
3
2
1,2-ETHANEDIOL1,2-ETHANEDIOL
4
2
DI(HYDROXYETHYL)ETHERDI(HYDROXYETHYL)ETHER
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303