4N64: Crystal structure of hemagglutinin from an H7N9 influenza virus in complex with a biantennary glycan receptor

Citation:
Abstract
The 2013 outbreak of avian-origin H7N9 influenza in eastern China has raised concerns about its ability to transmit in the human population. The hemagglutinin glycoprotein of most human H7N9 viruses carries Leu(226), a residue linked to adaptation of H2N2 and H3N2 pandemic viruses to human receptors. However, glycan array analysis of the H7 hemagglutinin reveals negligible binding to humanlike alpha2-6-linked receptors and strong preference for a subset of avian-like alpha2-3-linked glycans recognized by all avian H7 viruses. Crystal structures of H7N9 hemagglutinin and six hemagglutinin-glycan complexes have elucidated the structural basis for preferential recognition of avian-like receptors. These findings suggest that the current human H7N9 viruses are poorly adapted for efficient human-to-human transmission.
PDB ID: 4N64Download
MMDB ID: 116099
PDB Deposition Date: 2013/10/11
Updated in MMDB: 2013/12
Experimental Method:
x-ray diffraction
Resolution: 2.7014  Å
Source Organism:
Similar Structures:
Biological Unit for 4N64: hexameric; determined by author and by software (PISA)
Molecular Components in 4N64
Label Count Molecule
Proteins (6 molecules)
3
Hemagglutinin HA1
Molecule annotation
3
Hemagglutinin HA2
Molecule annotation
Chemicals (24 molecules)
1
15
2
3
3
3
4
3
* Click molecule labels to explore molecular sequence information.

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