4N5Z: Crystal Structure Of Aerosol Transmissible Influenza H5 Hemagglutinin Mutant (n158d, N224k, Q226l And T318i) From The Influenza Virus A/viet Nam/1203/2004 (h5n1)

Citation:
Abstract
Two ferret-adapted H5N1 viruses capable of respiratory droplet transmission have been reported with mutations in the hemagglutinin receptor-binding site and stalk domains. Glycan microarray analysis reveals that both viruses exhibit a strong shift toward binding to "human-type" alpha2-6 sialosides but with notable differences in fine specificity. Crystal structure analysis further shows that the stalk mutation causes no obvious perturbation of the receptor-binding pocket, consistent with its impact on hemagglutinin stability without affecting receptor specificity.
PDB ID: 4N5ZDownload
MMDB ID: 115346
PDB Deposition Date: 2013/10/10
Updated in MMDB: 2013/11
Experimental Method:
x-ray diffraction
Resolution: 2.95  Å
Source Organism:
Similar Structures:
Biological Unit for 4N5Z: hexameric; determined by author and by software (PISA)
Molecular Components in 4N5Z
Label Count Molecule
Proteins (6 molecules)
3
Hemagglutinin HA1 Chain
Molecule annotation
3
Hemagglutinin
Molecule annotation
Chemicals (10 molecules)
1
9
2
1
* Click molecule labels to explore molecular sequence information.

Citing MMDB
.