4N40: Crystal structure of human Epithelial cell-transforming sequence 2 protein

Citation:
Abstract
Homo sapiens ECT2 is a cell cycle regulator that plays critical roles in cytokinesis. ECT2 activity is restrained during interphase via intra-molecular interactions that involve its N-terminal triple-BRCT-domain and its C-terminal DH-PH domain. At anaphase, this self-inhibitory mechanism is relieved by Plk1-phosphorylated CYK-4, which directly engages the ECT2 BRCT domain. To provide a structural perspective for this auto-inhibitory property, we solved the crystal structure of the ECT2 triple-BRCT-domain. In addition, we systematically analyzed the interaction between the ECT2 BRCT domains with phospho-peptides derived from its binding partner CYK-4, and have identified Ser164 as the major phospho-residue that links CYK-4 to the second ECT2 BRCT domain.
PDB ID: 4N40Download
MMDB ID: 122706
PDB Deposition Date: 2013/10/8
Updated in MMDB: 2017/11
Experimental Method:
x-ray diffraction
Resolution: 3.106  Å
Source Organism:
Similar Structures:
Biological Unit for 4N40: monomeric; determined by author
Molecular Components in 4N40
Label Count Molecule
Protein (1 molecule)
1
Protein Ect2(Gene symbol: ECT2)
Molecule annotation
* Click molecule labels to explore molecular sequence information.

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