4N09: Structure Of Trypanosoma Brucei Brucei Adenosine Kinase In Complex With Adenosine And Amppnp

Citation:
Abstract
Trypanosoma brucei is a single-cellular parasite of the genus Kinetoplastida and is the causative agent of African sleeping sickness in humans. Adenosine kinase is a key enzyme in the purine-salvage pathway, phosphorylating adenosine to AMP, and also activates cytotoxic analogues such as cordycepin and Ara-A by their phosphorylation. The structures of T. brucei brucei adenosine kinase (TbAK) in its unliganded open conformation and complexed with adenosine and ADP in the closed conformation are both reported to 2.6 A resolution. The structures give insight into the binding mode of the substrates and the conformational change induced upon substrate binding. This information can be used to guide the improvement of cytotoxic substrate analogues as potential antitrypanosomal drugs.
PDB ID: 4N09Download
MMDB ID: 116680
PDB Deposition Date: 2013/10/1
Updated in MMDB: 2014/02
Experimental Method:
x-ray diffraction
Resolution: 2.6  Å
Source Organism:
Similar Structures:
Biological Unit for 4N09: monomeric; determined by author and by software (PISA)
Molecular Components in 4N09
Label Count Molecule
Protein (1 molecule)
1
Adenosine Kinase
Molecule annotation
Chemicals (3 molecules)
1
1
2
1
3
1
* Click molecule labels to explore molecular sequence information.

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