4MBI: Discovery Of Pyrazolo[1,5a]pyrimidine-based Pim1 Inhibitors

The synthesis and hit-to-lead SAR development from a pyrazolo[1,5-a]pyrimidine-derived hit 5 to the identification of a series of potent, pan-Pim inhibitors such as 11j are described.
PDB ID: 4MBIDownload
MMDB ID: 113631
PDB Deposition Date: 2013/8/19
Updated in MMDB: 2013/10
Experimental Method:
x-ray diffraction
Resolution: 2.3  Å
Source Organism:
Similar Structures:
Biological Unit for 4MBI: monomeric; determined by author and by software (PISA)
Molecular Components in 4MBI
Label Count Molecule
Protein (1 molecule)
Serine/threonine-protein Kinase Pim-1(Gene symbol: PIM1)
Molecule annotation
Chemical (1 molecule)
* Click molecule labels to explore molecular sequence information.

Citing MMDB