National Center for
4MBI: Discovery Of Pyrazolo[1,5a]pyrimidine-based Pim1 Inhibitors
Bioorg. Med. Chem. Lett. (2013) 23 p.6178-6182
The synthesis and hit-to-lead SAR development from a pyrazolo[1,5-a]pyrimidine-derived hit 5 to the identification of a series of potent, pan-Pim inhibitors such as 11j are described.