4M30: Crystal Structure Of Rnase Iii Complexed With Double-stranded Rna And Amp (type Ii Cleavage)

Citation:
Abstract
RNase III is a global regulator of gene expression in Escherichia coli that is instrumental in the maturation of ribosomal and other structural RNAs. We examine here how RNase III itself is regulated in response to growth and other environmental changes encountered by the cell and how, by binding or processing double-stranded RNA (dsRNA) intermediates, RNase III controls the expression of genes. Recent insight into the mechanism of dsRNA binding and processing, gained from structural studies of RNase III, is reviewed. Structural studies also reveal new cleavage sites in the enzyme that can generate longer 3' overhangs.
PDB ID: 4M30Download
MMDB ID: 115882
PDB Deposition Date: 2013/8/5
Updated in MMDB: 2013/12
Experimental Method:
x-ray diffraction
Resolution: 2.5  Å
Source Organism:
Aquifex aeolicus VF5
Similar Structures:
Biological Unit for 4M30: tetrameric; determined by author and by software (PISA)
Molecular Components in 4M30
Label Count Molecule
Proteins (2 molecules)
2
Ribonuclease 3(Gene symbol: rnc)
Molecule annotation
Nucleotide(1 molecule)
2
Rna12
Molecule annotation
Chemicals (12 molecules)
1
9
2
1
3
2
* Click molecule labels to explore molecular sequence information.

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