4LWT: The 1.6a Crystal Structure Of Humanized Xenopus Mdm2 With Ro5027344

The field of small-molecule inhibitors of protein-protein interactions is rapidly advancing and the specific area of inhibitors of the p53/MDM2 interaction is a prime example. Several groups have published on this topic and multiple compounds are in various stages of clinical development. Building on the strength of the discovery of RG7112, a Nutlin imidazoline-based compound, and RG7388, a pyrrolidine-based compound, we have developed additional scaffolds that provide opportunities for future development. Here, we report the discovery and optimization of a highly potent and selective series of spiroindolinone small-molecule MDM2 inhibitors, culminating in RO8994.
PDB ID: 4LWTDownload
MMDB ID: 121489
PDB Deposition Date: 2013/7/28
Updated in MMDB: 2014/08
Experimental Method:
x-ray diffraction
Resolution: 1.6  Å
Source Organism:
Similar Structures:
Biological Unit for 4LWT: monomeric; determined by author
Molecular Components in 4LWT
Label Count Molecule
Protein (1 molecule)
E3 Ubiquitin-protein Ligase Mdm2(Gene symbol: mdm2.S)
Molecule annotation
Chemicals (2 molecules)
* Click molecule labels to explore molecular sequence information.

Citing MMDB