4LVR: Crystal Structure Of Ift81 N-terminal Domain

Intraflagellar transport (IFT) of ciliary precursors such as tubulin from the cytoplasm to the ciliary tip is involved in the construction of the cilium, a hairlike organelle found on most eukaryotic cells. However, the molecular mechanisms of IFT are poorly understood. Here, we found that the two core IFT proteins IFT74 and IFT81 form a tubulin-binding module and mapped the interaction to a calponin homology domain of IFT81 and a highly basic domain in IFT74. Knockdown of IFT81 and rescue experiments with point mutants showed that tubulin binding by IFT81 was required for ciliogenesis in human cells.
PDB ID: 4LVRDownload
MMDB ID: 113452
PDB Deposition Date: 2013/7/26
Updated in MMDB: 2013/09
Experimental Method:
x-ray diffraction
Resolution: 2.6  Å
Source Organism:
Similar Structures:
Biological Unit for 4LVR: monomeric; determined by author
Molecular Components in 4LVR
Label Count Molecule
Protein (1 molecule)
Intraflagellar Transport Protein 81(Gene symbol: IFT81)
Molecule annotation
* Click molecule labels to explore molecular sequence information.

Citing MMDB