4LRS: Crystal and solution structures of the bifunctional enzyme (Aldolase/Aldehyde dehydrogenase) from Thermomonospora curvata, reveal a cofactor-binding domain motion during NAD+ and CoA accommodation whithin the shared cofactor-binding site

PDB ID: 4LRSDownload
MMDB ID: 236006
PDB Deposition Date: 2013/7/20
Updated in MMDB: 2023/11
Experimental Method:
x-ray diffraction
Resolution: 1.55  Å
Source Organism:
Thermomonospora curvata DSM 43183▼
Similar Structures:
Biological Unit for 4LRS: tetrameric; determined by author and by software (PISA)
Molecular Components in 4LRS
Label Count Molecule
Proteins (4 molecules)
2
4-hydroxy-2-oxovalerate Aldolase
Molecule annotation
2
Acetaldehyde Dehydrogenase
Molecule annotation
Chemicals and Non-standard biopolymers (40 molecules)
1
2
SULFATE IONSULFATE ION
2
2
PYRUVIC ACIDPYRUVIC ACID
3
4
CHLORIDE IONCHLORIDE ION
4
2
MAGNESIUM IONMAGNESIUM ION
5
12
GLYCEROLGLYCEROL
6
14
DI(HYDROXYETHYL)ETHERDI(HYDROXYETHYL)ETHER
7
2
NICOTINAMIDE-ADENINE-DINUCLEOTIDENICOTINAMIDE-ADENINE-DINUCLEOTIDE
8
2
FORMYL GROUPFORMYL GROUP
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303