4LLA: Crystal Structure Of D3d4 Domain Of The Lilrb2 Molecule

Leukocyte immunoglobulin-like receptors (LILRs), also called CD85s, ILTs, or LIRs, are important mediators of immune activation and tolerance that contain tandem immunoglobulin (Ig)-like folds. There are 11 (in addition to two pseudogenes) LILRs in total, two with two Ig-like domains (D1D2) and the remaining nine with four Ig-like domains (D1D2D3D4). Thus far, the structural features of the D1D2 domains of LILR proteins are well defined, but no structures for the D3D4 domains have been reported. This is a very important field to be studied as it relates to the unknown functions of the D3D4 domains, as well as their relative orientation to the D1D2 domains on the cell surface. Here, we report the crystal structures of the D3D4 domains of both LILRB1 and LILRB2. The two Iglike domains of both LILRB1-D3D4 and LILRB2-D3D4 are arranged at an acute angle ( approximately 60 degrees ) to form a bent structure, resembling the structures of natural killer inhibitory receptors. Based on these two D3D4 domain structures and previously reported D1D2/HLA I complex structures, two alternative models of full-length (four Ig-like domains) LILR molecules bound to HLA I are proposed.
PDB ID: 4LLADownload
MMDB ID: 113448
PDB Deposition Date: 2013/7/9
Updated in MMDB: 2013/11
Experimental Method:
x-ray diffraction
Resolution: 2.5  Å
Source Organism:
Similar Structures:
Biological Unit for 4LLA: monomeric; determined by author and by software (PISA)
Molecular Components in 4LLA
Label Count Molecule
Protein (1 molecule)
Leukocyte Immunoglobulin-like Receptor Subfamily B Member 2(Gene symbol: LILRB2)
Molecule annotation
* Click molecule labels to explore molecular sequence information.

Citing MMDB