4L74: Ca2+-bound MthK RCK domain at 1.9 Angstrom with single ligand

Citation:
Abstract
Ligand binding sites within proteins can interact by allosteric mechanisms to modulate binding affinities and control protein function. Here we present crystal structures of the regulator of K+ conductance (RCK) domain from a K+ channel, MthK, which reveal the structural basis of allosteric coupling between two Ca2+ regulatory sites within the domain. Comparison of RCK domain crystal structures in a range of conformations and with different numbers of regulatory Ca2+ ions bound, combined with complementary electrophysiological analysis of channel gating, suggests chemical interactions that are important for modulation of ligand binding and subsequent channel opening.
PDB ID: 4L74Download
MMDB ID: 114522
PDB Deposition Date: 2013/6/13
Updated in MMDB: 2017/11
Experimental Method:
x-ray diffraction
Resolution: 1.841  Å
Source Organism:
Similar Structures:
Biological Unit for 4L74: dimeric; determined by author and by software (PISA)
Molecular Components in 4L74
Label Count Molecule
Proteins (2 molecules)
2
Calcium-gated Potassium Channel Mthk(Gene symbol: MTH_RS07260)
Molecule annotation
Chemicals (2 molecules)
1
2
* Click molecule labels to explore molecular sequence information.

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