4KTS: Bovine Trypsin In Complex With Microviridin J At Ph 8.5

Citation:
Abstract
Understanding and controlling proteolysis is an important goal in therapeutic chemistry. Among the natural products specifically inhibiting proteases microviridins are particularly noteworthy. Microviridins are ribosomally produced and posttranslationally modified peptides that are processed into a unique, cagelike architecture. Here, we report a combined rational and random mutagenesis approach that provides fundamental insights into selectivity-conferring moieties of microviridins. The potent variant microviridin J was co-crystallized with trypsin, and for the first time the three-dimensional structure of microviridins was determined and the mode of inhibition revealed.
PDB ID: 4KTSDownload
MMDB ID: 118796
PDB Deposition Date: 2013/5/21
Updated in MMDB: 2014/05
Experimental Method:
x-ray diffraction
Resolution: 1.3  Å
Source Organism:
Microcystis aeruginosa MRC
Similar Structures:
Biological Unit for 4KTS: dimeric; determined by author and by software (PISA)
Molecular Components in 4KTS
Label Count Molecule
Proteins (2 molecules)
1
Cationic Trypsin(Gene symbol: PRSS1)
Molecule annotation
1
Microviridin
Molecule annotation
Chemicals (2 molecules)
1
1
2
1
* Click molecule labels to explore molecular sequence information.

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