National Center for
4KQ3: Crystal Structure Of Anti-il-17a Antibody Cnto3186
Proteins (2014) 82 p.1679-1683
Three Fab structures used as targets in the Antibody Modeling Assessment presented a challenge for modeling CDR-L3 due to deviations from the most typical canonical structure. In all three antibodies CDR-L3 has eight residues, which is one residue shorter than usual, and has a conformation that is rarely observed in crystal structures. We analyzed the sequence and structural determinants of this conformation and found that the "short" CDR-L3 is remarkably rigid and retains the conformation in the interactions with antigens and neighboring CDRs. Proteins 2014; 82:1679-1683. (c) 2014 Wiley Periodicals, Inc.