4KQ3: Crystal Structure Of Anti-il-17a Antibody Cnto3186

Citation:
Abstract
Three Fab structures used as targets in the Antibody Modeling Assessment presented a challenge for modeling CDR-L3 due to deviations from the most typical canonical structure. In all three antibodies CDR-L3 has eight residues, which is one residue shorter than usual, and has a conformation that is rarely observed in crystal structures. We analyzed the sequence and structural determinants of this conformation and found that the "short" CDR-L3 is remarkably rigid and retains the conformation in the interactions with antigens and neighboring CDRs. Proteins 2014; 82:1679-1683. (c) 2014 Wiley Periodicals, Inc.
PDB ID: 4KQ3Download
MMDB ID: 118585
PDB Deposition Date: 2013/5/14
Updated in MMDB: 2014/08
Experimental Method:
x-ray diffraction
Resolution: 1.92  Å
Source Organism:
Similar Structures:
Biological Unit for 4KQ3: dimeric; determined by author and by software (PISA)
Molecular Components in 4KQ3
Label Count Molecule
Proteins (2 molecules)
1
Cnto3186 Light Chain
Molecule annotation
1
Cnto3186 Heavy Chain
Molecule annotation
Chemicals (5 molecules)
1
3
2
1
3
1
* Click molecule labels to explore molecular sequence information.

Citing MMDB
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