4KPE: Novel fluoroquinolones in complex with topoisomerase IV from S. pneumoniae and E-site G-gate

PDB ID: 4KPEDownload
MMDB ID: 125006
PDB Deposition Date: 2013/5/13
Updated in MMDB: 2014/11
Experimental Method:
x-ray diffraction
Resolution: 3.43  Å
Source Organism:
Streptococcus pneumoniae TIGR4▼
Similar Structures:
Biological Unit for 4KPE: octameric; determined by author
Molecular Components in 4KPE
Label Count Molecule
Proteins (4 molecules)
2
DNA Topoisomerase 4 Subunit a
Molecule annotation
2
DNA Topoisomerase 4 Subunit B
Molecule annotation
Nucleotides(4 molecules)
1
E-site Dna1
Molecule annotation
1
E-site Dna2
Molecule annotation
1
E-site Dna3
Molecule annotation
1
E-site Dna4
Molecule annotation
Chemicals and Non-standard biopolymers (8 molecules)
1
6
MAGNESIUM IONMAGNESIUM ION
2
2
(7aR,8R)-8-amino-4-cyclopropyl-12-fluoro-1-oxo-4,7,7a,8,9,10-hexahydro-1H-pyrrolo[1',2':1,7]azepino[2,3-h]quinoline-2-carboxylic acid(7aR,8R)-8-amino-4-cyclopropyl-12-fluoro-1-oxo-4,7,7a,8,9,10-hexahydro-1H-pyrrolo[1',2':1,7]azepino[2,3-h]quinoline-2-carboxylic acid
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303