4KOM: The Structure Of Hemagglutinin From Avian-origin H7n9 Influenza Virus In Complex With Avian Receptor Analog 3'slnln (neuacα2- 3galβ1-4glcnacβ1-3galβ1-4glc)

An avian-origin human-infecting influenza (H7N9) virus was recently identified in China. We have evaluated the viral hemagglutinin (HA) receptor-binding properties of two human H7N9 isolates, A/Shanghai/1/2013 (SH-H7N9) (containing the avian-signature residue Gln(226)) and A/Anhui/1/2013 (AH-H7N9) (containing the mammalian-signature residue Leu(226)). We found that SH-H7N9 HA preferentially binds the avian receptor analog, whereas AH-H7N9 HA binds both avian and human receptor analogs. Furthermore, an AH-H7N9 mutant HA (Leu(226) --> Gln) was found to exhibit dual receptor-binding property, indicating that other amino acid substitutions contribute to the receptor-binding switch. The structures of SH-H7N9 HA, AH-H7N9 HA, and its mutant in complex with either avian or human receptor analogs show how AH-H7N9 can bind human receptors while still retaining the avian receptor-binding property.
PDB ID: 4KOMDownload
MMDB ID: 114895
PDB Deposition Date: 2013/5/12
Updated in MMDB: 2013/11
Experimental Method:
x-ray diffraction
Resolution: 2.6  Å
Source Organism:
Similar Structures:
Biological Unit for 4KOM: hexameric; determined by author and by software (PISA)
Molecular Components in 4KOM
Label Count Molecule
Proteins (6 molecules)
Hemagglutinin HA1
Molecule annotation
Hemagglutinin HA2
Molecule annotation
Chemicals (18 molecules)
* Click molecule labels to explore molecular sequence information.

Citing MMDB