4JU3: Crystal Structure Of Hcv Ns5b Polymerase In Complex With Compound 8

Citation:
Abstract
Optimization efforts on the anthranilic acid-based Thumb Pocket 2 HCV NS5B polymerase inhibitors 1 and 2 resulted in the identification of multiple structural elements that contributed to improved cell culture potency. The additive effect of these elements resulted in compound 46, an inhibitor with enzymatic (IC50) and cell culture (EC50) potencies of less than 100nanomolar.
PDB ID: 4JU3Download
MMDB ID: 115452
PDB Deposition Date: 2013/3/24
Updated in MMDB: 2013/12
Experimental Method:
x-ray diffraction
Resolution: 2  Å
Source Organism:
Similar Structures:
Biological Unit for 4JU3: monomeric; determined by author and by software (PISA)
Molecular Components in 4JU3
Label Count Molecule
Protein (1 molecule)
1
Genome Polyprotein
Molecule annotation
Chemicals (2 molecules)
1
1
2
1
* Click molecule labels to explore molecular sequence information.

Citing MMDB
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