4JTU: Crystal structure of human dihydroorotate dehydrogenase (DHODH) with brequinar analogue

PDB ID: 4JTUDownload
MMDB ID: 244443
PDB Deposition Date: 2013/3/24
Updated in MMDB: 2024/03
Experimental Method:
x-ray diffraction
Resolution: 1.9  Å
Source Organism:
Similar Structures:
Biological Unit for 4JTU: monomeric; determined by author
Molecular Components in 4JTU
Label Count Molecule
Protein (1 molecule)
1
Dihydroorotate Dehydrogenase (Quinone), Mitochondrial
(Gene symbol: DHODH)
Molecule annotation
Chemicals and Non-standard biopolymers (7 molecules)
1
1
FLAVIN MONONUCLEOTIDEFLAVIN MONONUCLEOTIDE
2
1
OROTIC ACIDOROTIC ACID
3
3
SULFATE IONSULFATE ION
4
1
UNDECYLAMINE-N,N-DIMETHYL-N-OXIDEUNDECYLAMINE-N,N-DIMETHYL-N-OXIDE
5
1
6-bromo-2-{4-[(2R)-butan-2-yl]phenyl}-3-methylquinoline-4-carboxylic acid6-bromo-2-{4-[(2R)-butan-2-yl]phenyl}-3-methylquinoline-4-carboxylic acid
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303