National Center for
4JA1: Structure Of Mmp3 Complexed With A Platinum-based Inhibitor
Chem. Commun. (Camb. ) (2013) 49 p.5492-5494
An X-ray investigation has been performed with the aim of characterizing the binding sites of a platinum-based inhibitor (K[PtCl3(DMSO)]) of matrix metalloproteinase-3 (stromelysin-1). The platinum complex targets His224 in the S1' specificity loop, representing the first step in the selective inhibition process (PDB ID code ).