4J52: Crystal Structure of Plk1 in Complex With a Pyrimidodiazepinone Inhibitor

Citation:
Abstract
Using structure-based drug design, we identified and optimized a novel series of pyrimidodiazepinone PLK1 inhibitors resulting in the selection of the development candidate TAK-960. TAK-960 is currently undergoing Phase I evaluation in adult patients with advanced solid malignancies.
PDB ID: 4J52Download
MMDB ID: 110546
PDB Deposition Date: 2013/2/7
Updated in MMDB: 2017/11
Experimental Method:
x-ray diffraction
Resolution: 2.3  Å
Source Organism:
Similar Structures:
Biological Unit for 4J52: monomeric; determined by author
Molecular Components in 4J52
Label Count Molecule
Protein (1 molecule)
1
Serine/threonine-protein Kinase Plk1(Gene symbol: PLK1)
Molecule annotation
Chemicals (3 molecules)
1
1
2
1
3
1
* Click molecule labels to explore molecular sequence information.

Citing MMDB
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