4IH7: Hepatitis C Virus Polymerase Ns5b (bk) With Fragment-based Compounds

The use of fragments with low binding affinity for their targets as starting points has received much attention recently. Screening of fragment libraries has been the most common method to find attractive starting points. Herein, we describe a unique, alternative approach to generating fragment leads. A binding model was developed and a set of guidelines were then selected to use this model to design fragments, enabling our discovery of a novel fragment with high LE.
PDB ID: 4IH7Download
MMDB ID: 111468
PDB Deposition Date: 2012/12/18
Updated in MMDB: 2013/07
Experimental Method:
x-ray diffraction
Resolution: 2.3  Å
Source Organism:
Similar Structures:
Biological Unit for 4IH7: monomeric; determined by author
Molecular Components in 4IH7
Label Count Molecule
Protein (1 molecule)
RNA-directed RNA Polymerase
Molecule annotation
Chemicals (2 molecules)
* Click molecule labels to explore molecular sequence information.

Citing MMDB