4I5M: Selective & Brain-Permeable Polo-like Kinase-2 (Plk-2) Inhibitors that Reduce -Synuclein Phosphorylation in Rat Brain

PDB ID: 4I5MDownload
MMDB ID: 243450
PDB Deposition Date: 2012/11/28
Updated in MMDB: 2024/03
Experimental Method:
x-ray diffraction
Resolution: 1.801  Å
Source Organism:
Similar Structures:
Biological Unit for 4I5M: monomeric; determined by author and by software (PISA)
Molecular Components in 4I5M
Label Count Molecule
Protein (1 molecule)
1
Serine/threonine-protein Kinase Plk2
(Gene symbol: PLK2)
Molecule annotation
Chemical and Non-standard biopolymers (1 molecule)
1
1
4-{[(7R)-8-cyclopentyl-7-ethyl-5-methyl-6-oxo-5,6,7,8-tetrahydropteridin-2-yl]amino}-3-methoxy-N-(1-methylpiperidin-4-yl)benzamide4-{[(7R)-8-cyclopentyl-7-ethyl-5-methyl-6-oxo-5,6,7,8-tetrahydropteridin-2-yl]amino}-3-methoxy-N-(1-methylpiperidin-4-yl)benzamide
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303