National Center for
4GES: Crystal Structure Of Gfp-Tyr151pyz With An Unnatural Amino Acid Incorporation
Angew. Chem. Int. Ed. Engl. (2012) 51 p.10261-10265
ET encounters jellyfish: Through the incorporation of the metal-chelating amino acid pyTyr into green fluorescent protein (GFP) from jellyfish, photoinduced electron transfer (ET) from the GFP chromophore to a bound Cu(II) ion was shown to occur within one nanosecond in a distance-dependent manner. The crystal structure of GFP with pyTyr at a specific position shows the structural basis for the nanomolar binding affinity of pyTyr to Cu(II) ions.