4ER3: Crystal Structure of Human DOT1L in complex with inhibitor EPZ004777

PDB ID: 4ER3Download
MMDB ID: 99759
PDB Deposition Date: 2012/4/19
Updated in MMDB: 2017/11
Experimental Method:
x-ray diffraction
Resolution: 2.4  Å
Source Organism:
Similar Structures:
Biological Unit for 4ER3: monomeric; determined by software (PISA)
Molecular Components in 4ER3
Label Count Molecule
Protein (1 molecule)
1
Histone-lysine N-methyltransferase, H3 Lysine-79 Specific
(Gene symbol: DOT1L)
Molecule annotation
Chemicals and Non-standard biopolymers (14 molecules)
1
1
7-{5-[(3-{[(4-tert-butylphenyl)carbamoyl]amino}propyl)(propan-2-yl)amino]-5-deoxy-beta-D-ribofuranosyl}-7H-pyrrolo[2,3-d]pyrimidin-4-amine7-{5-[(3-{[(4-tert-butylphenyl)carbamoyl]amino}propyl)(propan-2-yl)amino]-5-deoxy-beta-D-ribofuranosyl}-7H-pyrrolo[2,3-d]pyrimidin-4-amine
2
5
SULFATE IONSULFATE ION
3
2
1,2-ETHANEDIOL1,2-ETHANEDIOL
4
6
Molecule information is not available.
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303