National Center for
4ELT: Snapshot of the Large Fragment of DNA Polymerase I From Thermus Aquaticus Processing Modified Pyrimidines
Interactions of non-polar and "Click-able" nucleotides in the confines of a DNA polymerase active site
Chem. Commun. (Camb. ) (2012) 48 p.8320-8322
Modified nucleotides play a paramount role in many cutting-edge biomolecular techniques. The present structural study highlights the plasticity and flexibility of the active site of a DNA polymerase while incorporating non-polar "Click-able" nucleotide analogs and emphasizes new insights into rational design guidelines for modified nucleotides.