4E96: Crystal Structure of the first bromodomain of human BRD4 in complex with the inhibitor PFi-1

PDB ID: 4E96Download
MMDB ID: 98897
PDB Deposition Date: 2012/3/20
Updated in MMDB: 2012/11
Experimental Method:
x-ray diffraction
Resolution: 1.92  Å
Source Organism:
Similar Structures:
Biological Unit for 4E96: monomeric; determined by author and by software (PISA)
Molecular Components in 4E96
Label Count Molecule
Protein (1 molecule)
1
Bromodomain-containing Protein 4
(Gene symbol: BRD4)
Molecule annotation
Chemicals and Non-standard biopolymers (4 molecules)
1
1
2-methoxy-N-(3-methyl-2-oxo-1,2,3,4-tetrahydroquinazolin-6-yl)benzenesulfonamide2-methoxy-N-(3-methyl-2-oxo-1,2,3,4-tetrahydroquinazolin-6-yl)benzenesulfonamide
2
1
SODIUM IONSODIUM ION
3
1
DIMETHYL SULFOXIDEDIMETHYL SULFOXIDE
4
1
1,2-ETHANEDIOL1,2-ETHANEDIOL
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303