4E6D: JAK2 kinase (JH1 domain) triple mutant in complex with compound 7

PDB ID: 4E6DDownload
MMDB ID: 100144
PDB Deposition Date: 2012/3/15
Updated in MMDB: 2012/07
Experimental Method:
x-ray diffraction
Resolution: 2.22  Å
Source Organism:
Similar Structures:
Biological Unit for 4E6D: dimeric; determined by author and by software (PISA)
Molecular Components in 4E6D
Label Count Molecule
Proteins (2 molecules)
2
Tyrosine-protein Kinase Jak2
(Gene symbol: JAK2)
Molecule annotation
Chemicals and Non-standard biopolymers (3 molecules)
1
2
3-[(3R)-3-(imidazo[4,5-d]pyrrolo[2,3-b]pyridin-1(6H)-yl)piperidin-1-yl]-3-oxopropanenitrile (Link to PubChem not yet available)3-[(3R)-3-(imidazo[4,5-d]pyrrolo[2,3-b]pyridin-1(6H)-yl)piperidin-1-yl]-3-oxopropanenitrile
2
1
GLYCEROL (Link to PubChem not yet available)GLYCEROL
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303