4DYM: Crystal structure of the ACVR1 kinase domain in complex with the imidazo[1,2-b]pyridazine inhibitor K00135

PDB ID: 4DYMDownload
MMDB ID: 98273
PDB Deposition Date: 2012/2/29
Updated in MMDB: 2023/09
Experimental Method:
x-ray diffraction
Resolution: 2.42  Å
Source Organism:
Similar Structures:
Biological Unit for 4DYM: dimeric; determined by software (PISA)
Molecular Components in 4DYM
Label Count Molecule
Proteins (2 molecules)
2
Activin Receptor Type-1
(Gene symbol: ACVR1)
Molecule annotation
Chemicals and Non-standard biopolymers (14 molecules)
1
4
SULFATE IONSULFATE ION
2
2
1-(3-{6-[(CYCLOPROPYLMETHYL)AMINO]IMIDAZO[1,2-B]PYRIDAZIN-3-YL}PHENYL)ETHANONE1-(3-{6-[(CYCLOPROPYLMETHYL)AMINO]IMIDAZO[1,2-B]PYRIDAZIN-3-YL}PHENYL)ETHANONE
3
8
GLYCEROLGLYCEROL
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303