4DL7: Human DNA polymerase eta fails to extend primer 2 nucleotide after cisplatin crosslink (Pt-GG4)

PDB ID: 4DL7Download
MMDB ID: 99423
PDB Deposition Date: 2012/2/5
Updated in MMDB: 2023/09
Experimental Method:
x-ray diffraction
Resolution: 1.97  Å
Source Organism:
synthetic construct▼
Similar Structures:
Biological Unit for 4DL7: trimeric; determined by author and by software (PISA)
Molecular Components in 4DL7
Label Count Molecule
Protein (1 molecule)
1
DNA Polymerase ETA
Molecule annotation
Nucleotides(2 molecules)
1
DNA (5'-d(*tp*ap*cp*tp*cp*gp*gp*tp*cp*ap*cp*t)-3')
Molecule annotation
1
DNA (5'-d(*tp*ap*gp*tp*gp*ap*cp*cp*g)-3')
Molecule annotation
Chemicals and Non-standard biopolymers (3 molecules)
1
1
GLYCEROLGLYCEROL
2
1
2'-deoxy-5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]adenosine2'-deoxy-5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]adenosine
3
1
CisplatinCisplatin
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303