4DHM: Small-molecule Inhibitors Of 14-3-3 Protein-protein Interactions From Virtual Screening

Citation:
Abstract
We report first non-covalent and exclusively extracellular inhibitors of 14-3-3 protein-protein interactions identified by virtual screening. Optimization by crystal structure analysis and in vitro binding assays yielded compounds capable of disrupting the interaction of 14-3-3sigma with aminopeptidase N in a cellular assay.
PDB ID: 4DHMDownload
MMDB ID: 112187
PDB Deposition Date: 2012/1/30
Updated in MMDB: 2013/09
Experimental Method:
x-ray diffraction
Resolution: 1.7  Å
Source Organism:
Similar Structures:
Biological Unit for 4DHM: dimeric; determined by author and by software (PISA)
Molecular Components in 4DHM
Label Count Molecule
Proteins (2 molecules)
2
14-3-3 Protein Sigma(Gene symbol: SFN)
Molecule annotation
Chemicals (14 molecules)
1
6
2
4
3
2
4
2
* Click molecule labels to explore molecular sequence information.

Citing MMDB
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