4DFN: Crystal structure of spleen tyrosine kinase complexed with an adamantylpyrazine inhibitor

PDB ID: 4DFNDownload
MMDB ID: 99072
PDB Deposition Date: 2012/1/24
Updated in MMDB: 2018/04
Experimental Method:
x-ray diffraction
Resolution: 2.48  Å
Source Organism:
Similar Structures:
Biological Unit for 4DFN: monomeric; determined by author and by software (PISA)
Molecular Components in 4DFN
Label Count Molecule
Protein (1 molecule)
1
Tyrosine-protein Kinase SYK
(Gene symbol: SYK)
Molecule annotation
Chemical and Non-standard biopolymers (1 molecule)
1
1
3-amino-6-[3-(1-methyl-1H-pyrazol-4-yl)phenyl]-N-[(1R,2r,3S,5s,7s)-5-hydroxyadamantan-2-yl]pyrazine-2-carboxamide3-amino-6-[3-(1-methyl-1H-pyrazol-4-yl)phenyl]-N-[(1R,2r,3S,5s,7s)-5-hydroxyadamantan-2-yl]pyrazine-2-carboxamide
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303