4DD8: Adam-8 Metalloproteinase Domain With Bound Batimastat

Citation:
Abstract
The role of ADAM-8 in cancer and inflammatory diseases such as allergy, arthritis and asthma makes it an attractive target for drug development. Therefore, the catalytic domain of human ADAM-8 was expressed, purified and crystallized in complex with a hydroxamic acid inhibitor, batimastat. The crystal structure of the enzyme-inhibitor complex was refined to 2.1 A resolution. ADAM-8 has an overall fold similar to those of other ADAM members, including a central five-stranded beta-sheet and a catalytic Zn(2+) ion. However, unique differences within the S1' binding loop of ADAM-8 are observed which might be exploited to confer specificity and selectivity to ADAM-8 competitive inhibitors for the treatment of diseases involving this enzyme.
PDB ID: 4DD8Download
MMDB ID: 100317
PDB Deposition Date: 2012/1/18
Updated in MMDB: 2012/06
Experimental Method:
x-ray diffraction
Resolution: 2.1  Å
Source Organism:
Similar Structures:
Biological Unit for 4DD8: monomeric; determined by author and by software (PISA)
Molecular Components in 4DD8
Label Count Molecule
Protein (1 molecule)
1
Disintegrin and Metalloproteinase Domain-containi 8
Molecule annotation
Chemicals (9 molecules)
1
2
2
1
3
1
4
2
5
1
6
2
* Click molecule labels to explore molecular sequence information.

Citing MMDB
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