4D08: Pde2a Catalytic Domain In Complex With A Brain Penetrant Inhibitor

Citation:
Abstract
Structure-guided design led to the identification of the novel, potent, and selective phosphodiesterase 2 (PDE2) inhibitor 12. Compound 12 demonstrated a >210-fold selectivity versus PDE10 and PDE11 and was inactive against all other PDE family members up to 10 muM. In vivo evaluation of 12 provided evidence that it is able to engage the target and to increase cGMP levels in relevant brain regions. Hence, 12 is a valuable tool compound for the better understanding of the role of PDE2 in cognitive impairment and other central nervous system related disorders.
PDB ID: 4D08Download
MMDB ID: 122117
PDB Deposition Date: 2014/4/24
Updated in MMDB: 2014/10
Experimental Method:
x-ray diffraction
Resolution: 1.9  Å
Source Organism:
Similar Structures:
Biological Unit for 4D08: monomeric; determined by author and by software (PISA)
Molecular Components in 4D08
Label Count Molecule
Protein (1 molecule)
1
Cgmp-dependent 3', 5'-cyclic Phosphodiesterase(Gene symbol: PDE2A)
Molecule annotation
Chemicals (3 molecules)
1
1
2
1
3
1
* Click molecule labels to explore molecular sequence information.

Citing MMDB
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