4CVZ: Complex Of A B21 Chicken Mhc Class I Molecule And A 10mer Chicken Peptide

Highly polymorphic MHC molecules are at the heart of adaptive immune responses, playing crucial roles in many kinds of disease and in vaccination. We report that breadth of peptide presentation and level of cell surface expression of class I molecules are inversely correlated in both chickens and humans. This relationship correlates with protective responses against infectious pathogens including Marek's disease virus leading to lethal tumours in chickens and HIV infection progressing to AIDS in humans. We propose that differences in peptide binding repertoire define two groups of MHC class I molecules strategically evolved as generalists and specialists for different modes of pathogen resistance. We suggest that differences in cell surface expression level ensure the development of optimal peripheral T cell responses. The inverse relationship of peptide repertoire and expression is evidently a fundamental property of MHC molecules, with ramifications extending beyond immunology and medicine to evolutionary biology and conservation.
PDB ID: 4CVZDownload
MMDB ID: 128987
PDB Deposition Date: 2014/3/31
Updated in MMDB: 2015/05
Experimental Method:
x-ray diffraction
Resolution: 2.39  Å
Source Organism:
Similar Structures:
Biological Unit for 4CVZ: trimeric; determined by author and by software (PISA)
Molecular Components in 4CVZ
Label Count Molecule
Proteins (3 molecules)
Major Histocompatibility Complex Class I Glycoprotein Haplotype B21
Molecule annotation
Molecule annotation
Beta-2-microglobulin(Gene symbol: B2M)
Molecule annotation
Chemicals (6 molecules)
* Click molecule labels to explore molecular sequence information.

Citing MMDB