4CM8: Crystal structure of pteridine reductase 1 (PTR1) from Trypanosoma brucei in ternary complex with cofactor and inhibitor

PDB ID: 4CM8Download
MMDB ID: 240430
PDB Deposition Date: 2014/1/15
Updated in MMDB: 2023/12
Experimental Method:
x-ray diffraction
Resolution: 1.9  Å
Source Organism:
Similar Structures:
Biological Unit for 4CM8: tetrameric; determined by software (PISA)
Molecular Components in 4CM8
Label Count Molecule
Proteins (4 molecules)
3
Pteridine Reductase 1
Molecule annotation
1
Pteridine Reductase 1
Molecule annotation
Chemicals and Non-standard biopolymers (14 molecules)
1
4
NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATENADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
2
4
(E)-2,4-diamino-6-(4-methylstyryl)-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile(E)-2,4-diamino-6-(4-methylstyryl)-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile
3
2
ACETATE IONACETATE ION
4
2
2,3-DIHYDROXY-1,4-DITHIOBUTANE2,3-DIHYDROXY-1,4-DITHIOBUTANE
5
2
GLYCEROLGLYCEROL
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303