4CJX: The crystal structure of Trypanosoma brucei N5, N10- methylenetetrahydrofolate dehydrogenase-cyclohydrolase (FolD) complexed with NADP cofactor and inhibitor

PDB ID: 4CJXDownload
MMDB ID: 126602
PDB Deposition Date: 2013/12/23
Updated in MMDB: 2023/12
Experimental Method:
x-ray diffraction
Resolution: 2.05  Å
Source Organism:
Similar Structures:
Biological Unit for 4CJX: dimeric; determined by author and by software (PISA)
Molecular Components in 4CJX
Label Count Molecule
Proteins (2 molecules)
2
C-1-tetrahydrofolate Synthase, Cytoplasmic, Putative
Molecule annotation
Chemicals and Non-standard biopolymers (5 molecules)
1
1
GLYCEROLGLYCEROL
2
1
DI(HYDROXYETHYL)ETHERDI(HYDROXYETHYL)ETHER
3
2
(2S)-2-[[4-[[2,4-bis(azanyl)-6-oxidanylidene-1H-pyrimidin-5-yl]carbamoylamino]phenyl]carbonylamino]pentanedioic acid(2S)-2-[[4-[[2,4-bis(azanyl)-6-oxidanylidene-1H-pyrimidin-5-yl]carbamoylamino]phenyl]carbonylamino]pentanedioic acid
4
1
NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATENADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303