4CFX: Structure-based Design Of C8-substituted O6-cyclohexylmethoxyguanine Cdk1 And 2 Inhibitors

PDB ID: 4CFXDownload
MMDB ID: 125351
PDB Deposition Date: 2013/11/19
Updated in MMDB: 2014/12
Experimental Method:
x-ray diffraction
Resolution: 3.5  Å
Source Organism:
Similar Structures:
Biological Unit for 4CFX: dimeric; determined by software (PISA)
Molecular Components in 4CFX
Label Count Molecule
Proteins (2 molecules)
1
Cyclin-dependent Kinase 2
(Gene symbol: CDK2)
Molecule annotation
1
Cyclin-a2
(Gene symbol: CCNA2)
Molecule annotation
Chemical and Non-standard biopolymers (1 molecule)
1
1
3-[2-Amino-6-(Cyclohexylmethoxy)-7h-Purin-8-Yl]benzenesulfonamide3-[2-Amino-6-(Cyclohexylmethoxy)-7h-Purin-8-Yl]benzenesulfonamide
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303