4CB9: Structure Of Full-length Ctnnbl1 In P43212 Space Group

Citation:
Abstract
CTNNBL1 is a spliceosome-associated protein that binds nuclear localization signals (NLSs) in splice factors CDC5L and Prp31 as well as the antibody diversifying enzyme AID. Here, crystal structures of human CTNNBL1 reveal a distinct structure from its closest homologue karyopherin-alpha. CTNNBL1 comprises a HEAT-like domain (including a nuclear export signal), a central armadillo domain, and a coiled-coil C-terminal domain. Structure-guided mutations of the region homologous to the karyopherin-alpha NLS-binding site fail to disrupt CTNNBL1-NLS interactions. Our results identify CTNNBL1 as a unique selective NLS-binding protein with striking differences from karyopherin-alphas.
PDB ID: 4CB9Download
MMDB ID: 115625
PDB Deposition Date: 2013/10/10
Updated in MMDB: 2013/12
Experimental Method:
x-ray diffraction
Resolution: 3  Å
Source Organism:
Similar Structures:
Biological Unit for 4CB9: monomeric; determined by software (PISA)
Molecular Components in 4CB9
Label Count Molecule
Protein (1 molecule)
1
Beta-catenin-like Protein 1(Gene symbol: CTNNBL1)
Molecule annotation
* Click molecule labels to explore molecular sequence information.

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