4CA9: Structure of the Nucleoplasmin-like N-terminal domain of Drosophila FKBP39

Nucleoplasmin is a histone chaperone that consists of a pentameric N-terminal domain and an unstructured C-terminal tail. The pentameric core domain, a doughnut-like structure with a central pore, is only found in the nucleoplasmin family. Here, we report the first structure of a nucleoplasmin-like domain (NPL) from the unrelated Drosophila protein, FKBP39, and we present evidence that this protein associates with chromatin. Furthermore, we show that two other chromatin proteins, Arabidopsis thaliana histone deacetylase type 2 (HD2) and Saccharomyces cerevisiae Fpr4, share the NPL fold and form pentamers, or a dimer of pentamers in the case of HD2. Thus, we propose a new family of proteins that share the pentameric nucleoplasmin-like NPL domain and are found in protists, fungi, plants and animals.
PDB ID: 4CA9Download
MMDB ID: 124282
PDB Deposition Date: 2013/10/7
Updated in MMDB: 2014/11
Experimental Method:
solution nmr
Source Organism:
Similar Structures:
Biological Unit for 4CA9: pentameric; determined by author and by software (PQS)
Molecular Components in 4CA9
Label Count Molecule
Proteins (5 molecules)
39 KDA Fk506-binding Nuclear Protein(Gene symbol: FK506-bp1)
Molecule annotation
* Click molecule labels to explore molecular sequence information.

Citing MMDB