4C68: Plasmodium Vivax N-myristoyltransferase In Complex With A Peptidomimetic Inhibitor

Citation:
Abstract
N-Myristoyltransferase (NMT) has been shown to be essential in Leishmania and subsequently validated as a drug target in Plasmodium. Herein, we discuss the use of antifungal NMT inhibitors as a basis for inhibitor development resulting in the first sub-micromolar peptidomimetic inhibitors of Plasmodium and Leishmania NMTs. High-resolution structures of these inhibitors with Plasmodium and Leishmania NMTs permit a comparative analysis of binding modes, and provide the first crystal structure evidence for a ternary NMT-Coenzyme A/myristoylated peptide product complex.
PDB ID: 4C68Download
MMDB ID: 123336
PDB Deposition Date: 2013/9/17
Updated in MMDB: 2014/10
Experimental Method:
x-ray diffraction
Resolution: 1.38  Å
Source Organism:
Similar Structures:
Biological Unit for 4C68: monomeric; determined by author and by software (PISA)
Molecular Components in 4C68
Label Count Molecule
Protein (1 molecule)
1
Glycylpeptide N-tetradecanoyltransferase
Molecule annotation
Chemicals (8 molecules)
1
1
2
2
3
1
4
1
5
1
6
1
7
1
* Click molecule labels to explore molecular sequence information.

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