4BQU: Japanin from Rhipicephalus appendiculatus bound to cholesterol: Orthorhombic crystal form

Citation:
Abstract
Two crystal structures of Japanin, an 18 kDa immune-modulatory lipocalin from the Brown Ear Tick (Rhipicephalus appendiculatus), have been determined at 2.2 and 2.4 A resolution. In both crystal forms the protein is in complex with cholesterol, which sits in a closed pocket at the centre of the lipocalin barrel. Both crystal forms are dimers, which are also observed in solution. Molecular modelling suggests that previously-described members of a tick protein family bearing high sequence homology to Japanin are also likely to bind cholesterol or cholesterol derivatives.
PDB ID: 4BQUDownload
MMDB ID: 120735
PDB Deposition Date: 2013/6/2
Updated in MMDB: 2018/06
Experimental Method:
x-ray diffraction
Resolution: 2.36  Å
Source Organism:
Similar Structures:
Biological Unit for 4BQU: monomeric; determined by author and by software (PISA)
Molecular Components in 4BQU
Label Count Molecule
Protein (1 molecule)
1
Japanin
Molecule annotation
Chemicals (15 molecules)
1
1
2
6
3
4
4
1
5
1
6
2
* Click molecule labels to explore molecular sequence information.

Citing MMDB
.