National Center for
4BPE: The Crystal Structure Of The Eukaryotic 40s Ribosomal Subunit In Complex With Eif1 And Eif1a - Complex 1
Nat. Struct. Mol. Biol. (2013) 20 p.1015-1017
Eukaryotic translation initiation factors (eIFs) 1A and 1 are central players in the complex process of start-codon recognition. To improve mechanistic understanding of this process, we determined the crystal structure of the 40S ribosomal subunit in complex with eIF1A and eIF1 from Tetrahymena thermophila at a resolution of 3.7 A. It reveals the positions of the two factors on the 40S and the conformational changes that accompany their binding.