4B14: Plasmodium Vivax N-Myristoyltransferase With A Bound Benzofuran Inhibitor (Compound 26)

Citation:
Abstract
Design of inhibitors for N-myristoyltransferase (NMT), an enzyme responsible for protein trafficking in Plasmodium falciparum , the most lethal species of parasites that cause malaria, is described. Chemistry-driven optimization of compound 1 from a focused NMT inhibitor library led to the identification of two early lead compounds 4 and 25, which showed good enzyme and cellular potency and excellent selectivity over human NMT. These molecules provide a valuable starting point for further development.
PDB ID: 4B14Download
MMDB ID: 104017
PDB Deposition Date: 2012/7/6
Updated in MMDB: 2012/11
Experimental Method:
x-ray diffraction
Resolution: 1.5  Å
Source Organism:
Similar Structures:
Biological Unit for 4B14: monomeric; determined by software (PISA)
Molecular Components in 4B14
Label Count Molecule
Protein (1 molecule)
1
Glycylpeptide N-tetradecanoyltransferase
Molecule annotation
Chemicals (6 molecules)
1
1
2
1
3
1
4
1
5
1
6
1
* Click molecule labels to explore molecular sequence information.

Citing MMDB
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