4B03: 6a Electron Cryomicroscopy Structure Of Immature Dengue Virus Serotype 1

Citation:
Abstract
Dengue virus is a major human pathogen that has four serotypes (DENV1 to -4). Here we report the cryoelectron microscopy (cryo-EM) structures of immature and mature DENV1 at 6- and 4.5-A resolution, respectively. The subnanometer-resolution maps allow accurate placement of all of the surface proteins. Although the immature and mature viruses showed vastly different surface protein organizations, the envelope protein transmembrane (E-TM) regions remain in similar positions. The pivotal role of the E-TM regions leads to the identification of the start and end positions of all surface proteins during maturation.
PDB ID: 4B03Download
MMDB ID: 110640
PDB Deposition Date: 2012/6/28
Updated in MMDB: 2017/09
Experimental Method:
electron microscopy
Resolution: 6  Å
Source Organism:
Similar Structures:
Biological Unit for 4B03: 360-meric
Molecular Components in 4B03
Label Count Molecule
Proteins (360 molecules)
180
Dengue Virus 1 E Protein
Molecule annotation
180
Dengue Virus 1 PRM Protein
Molecule annotation
* Click molecule labels to explore molecular sequence information.

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